Endocrine Abstracts

Introduction: The start of GH (rhGH) treatment in children with GH deficiency (GHD) causes a significant increase in bone turnover and increases height velocity. The increase in IGF1 concentrations during rhGH treatment is a marker of the efficiency of treatment. Bone age delay at baseline is related to GHD and is a good predictor of height velocity during treatment. A significant increase in bone turnover during rhGH treatment results in an increased demand for vitamin D. It ...

Forkhead box P3 (Foxp3) is an important regulatory factor for the development and function of T regulatory cells (Tregs). Moreover it has been established that deficiency of the Foxp3 gene in Treg cells suppresses their regulatory function leading to the development of autoimmune thyroid diseases (AITDs). The aim of our study was to estimate the association of three polymorphism of FOXP3 gene with the predisposition to GD and HT in children.<p class="abst...